Endocrine Abstracts

Context: Diabetes mellitus represents one of the most frequent metabolic comorbidities and occurs in 30% to 40% of patients with acromegaly. Patients with acromegaly develop insulin resistance due to GH excess, and in those with longstanding disease, insulin deficiency may occur. Moreover, the use of second-generation somatostatin receptor ligands (SRLs) pasireotide might contribute to the increased development in new-onset diabetes and the worsening of hyperglycemia. Manageme...

Introduction: Acromegaly is a chronic disease generally caused by a GH-secreting pituitary adenoma. GH excess causes insulin resistance and impair β cell function, predisposing patients with acromegaly to develop DM. Treatment of diabetes has been revolutionized since the introduction of sodium-glucose cotransporter inhibitors (SGLT2i). This novel class is widely used in type 2 diabetes mellitus (T2DM) and recently was approved for patients with heart failure with reduced...

Introduction: Metastatic or locally advanced prostate cancer is treated with surgical or medical hormone therapy. Preservation of the patient’s quality of life is a major parameter that influences the management at this stage. Comparative studies between both types of hormone therapy that consider the patient’s quality of life are almost nonexistent. The objective of our study is to evaluate the impact of medical and surgical castration on the quality of life in pati...